Adequate research space and updated research facilities are critical to the research mission of universities and academic health centers nationwide. However, much of the existing biomedical research infrastructure at these institutions was built 30 or more years ago, and academic health center leaders face a growing challenge to fund the crucial research facilities that benefit the nation. This report presents the latest data on research facilities, current funding sources, and construction costs, and includes several recommendations to help academic health centers ensure that the nation’s research infrastructure is viable for the future.